A Reverse Genetics Approach To Study Feline Infectious Peritonitis

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A reverse genetics approach to study feline infectious peritonitis.

Feline infectious peritonitis (FIP) is a lethal immunopathological disease caused by feline coronaviruses (FCoVs). Here, we describe a reverse genetics approach to study FIP by assessing the pathogenicity of recombinant type I and type II and chimeric type I/type II FCoVs. All recombinant FCoVs established productive infection in cats, and recombinant type II FCoV (strain 79-1146) induced FIP. ...

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Understanding Feline Infectious Peritonitis

Dr. Niels C. Pedersen is Director of the Veterinary Genetics Laboratory and Director of the Center for Companion Animal Health at the University of California at Davis. Dr. Pedersen is an international authority on infectious diseases and immunological disorders in small animals and in comparative genetics. His current areas of research focus on infectious diseases of cats and dogs in shelter a...

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Feline infectious peritonitis.

The article discusses feline infectious peritonitis (FIP), an important disease frequently seen in veterinary practice. FIP causes many problems to the veterinarian as it can be difficult to definitively diagnose the disease, as there is no effective treatment, and as prophylactic interventions are not very successful. Although intense research has created a lot of new knowledge about this dise...

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Feline infectious peritonitis.

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Genetics and Pathogenesis of Feline Infectious Peritonitis Virus

Feline coronavirus (FCoV) is endemic in feral cat populations and cat colonies, frequently preceding outbreaks of fatal feline infectious peritonitis (FIP). FCoV exhibits 2 biotypes: the pathogenic disease and a benign infection with feline enteric coronavirus (FECV). Uncertainty remains regarding whether genetically distinctive avirulent and virulent forms coexist or whether an avirulent form ...

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ژورنال

عنوان ژورنال: Journal of Virology

سال: 2012

ISSN: 0022-538X,1098-5514

DOI: 10.1128/jvi.00023-12